Systemic lupus erythematosus is a disease that continues to evolve over time. If a patient meets at least four criteria, lupus can be diagnosed with 95% specificity and 85% sensitivity. The recent attempts to create modern criteria for the classification of sle have aimed at being more sensitive, clinically relevant and meaningful than the older american college of rheumatology acr classification criteria. Objective to develop new classification criteria for systemic lupus erythematosus sle jointly supported by the european league against rheumatism eular and the. Diagnostic criteria for systemic lupus erythematosus. Systemic lupus erythematosus sle is a chronic, multisystem autoimmune disease characterized by disorder of the generation of autoantibodies to components of cell nucleus, and the exact. Many studies have explored the pathology of systemic lupus erythematosus sle, an autoimmune rheumatic disorder with a striking female predominance. Systemic lupus erythematosus is a systemic autoimmune disease with a worldwide distribution. Indeed, it is the diversity of presentation, accumulation of manifestations over time, and undulating disease course that challenge the most astute of clinicians. In 2012, the systemic lupus international collaborating clinics slicc network presented a set of criteria based on almost 1400 patient scenarios, including a derivation and a validation of the new criteria as well as of the 1997 acr classification.
Systemic lupus erythematosus sle is a spectrum of autoimmune disease in which defects can occur at multiple points of the immune cascade, resulting in a striking heterogeneity of clinical. Systemic lupus erythematosus is a chronic autoimmune condition that causes inflammation in the bodys tissues. With rare exception, the unifying laboratory abnormality is. Researchers from around the world contributed to the development of classification criteria for systemic lupus erythematosus sle designed to distinguish the. Although both men and women of all age groups can be affected, women outnumber men almost 10 fold and. Pdf toward new criteria for systemic lupus erythematosus. The slicc group is an international group of investigators dedicated to clinical research on sle.
In the validation cohort, the new criteria had a sensitivity of 96. New acr, eular criteria distinguish lupus from imitators. The 2012 revised slicc criteria for classification of. Hydroxychloroquine is the cornerstone of treatment because it reduces disease flares and other constitutional symptoms. All patients with lupus should receive education, counseling, and support. The most recent addendum to the classification criteria for sle dates from 2012, when the systemic lupus international collaborating clinics slicc group published a revision and validation of the acr criteria 5. Systemic lupus erythematosus, the most common form of lupus, is a chronic autoimmune disease that can cause severe fatigue and joint pain. The diagnostic accuracies of the 2012 slicc criteria and. Thus, a patient who presents with skin and joint disease remains at risk for renal disease even after having lupus. Discoid rash raised erythematous patches with keratotic scaling, follicular plugging, and atrophic scarring 3.
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